Dr. Patrick Hennessey

Dr. Patrick Hennessey

Dr. Hennessey graduated from Carleton College in Northfield, Minnesota with honors, earning a bachelor’s degree in Biology with a concentration in Biochemistry. After graduation, he was awarded a Post-Baccalaureate Intramural Research Training Award Fellowship at the National Institutes of Health (NIH) in Bethesda, Maryland. He subsequently attended the Georgetown University School of Medicine in Washington, DC.

Dr. Hennessey went on to complete his residency training in Otolaryngology at the Johns Hopkins Hospital in Baltimore, Maryland. During his training, he received a NIH grant that allowed him to spend two years investigating the molecular underpinnings of head and neck and lung cancers. In addition to his research, he also served on the Patient Safety and Quality Improvement Committee of American Academy of Otolaryngology-Head and Neck Surgery while in residency

Dr. Hennessey is Board Certified by the American Board of Otolaryngology. He has published multiple articles in peer-reviewed journals and has presented his research at national scientific meetings, and he continues to be involved in scientific research. Dr. Hennessey has a particular interest in chronic sinusitis, environmental allergies, and endoscopic sinus surgery; however, he enjoys practicing all aspects of general Otolaryngology. He holds privileges at Sparrow Hospital, McLaren Greater Lansing Medical Center, and the Michigan Surgical Center.

Publications

  • Gaykalova DA, Manola JB, Ozawa H, Zizkova V, Morton K, Bishop JA, Sharma R, Zhang C, Michailidi C, Considine M, Tan M, Fertig EJ, Hennessey PT, Ahn J, Koch WM, Westra WH, Khan Z, Chung CH, Ochs MF, Califano JA. NF-κB and stat3 transcription factor signatures differentiate HPV-positive and HPV-negative head and neck squamous cell carcinoma. Int J Cancer. 2015 Oct 15;137(8):1879-89
  • Mydlarz WK, Hennessey PT, Wang H, Carvalho AL, Califano JA. Serum biomarkers for detection of head and neck squamous cell carcinoma. 2014 Jul 3. doi: 10.1002/hed.23842. [Epub ahead of print]
  • Li R, Ochs MF, Ahn SM, Hennessey P, Tan M, Soudry E, Gaykalova DA, Uemura M, Brait M, Shao C, Westra W, Bishop J, Fertig EJ, Califano JA. Expression microarray analysis reveals alternative splicing of LAMA3 and DST genes in head and neck squamous cell carcinoma. PLoS One. 2014 Mar 27;9(3):e91263.
  • Gaykalova DA, Mambo E, Choudhary A, Houghton J, Buddavarapu K, Sanford T, Darden W, Adai A, Hadd A, Latham G, Danilova LV, Bishop J, Li RJ, Westra WH, Hennessey P, Koch WM, Ochs MF, Califano JA, Sun W. Novel insight into mutational landscape of head and neck squamous cell carcinoma. PLoS One. 2014 Mar 25;9(3):e93102
  • Sun W, Gaykalova DA, Ochs MF, Mambo E, Arnaoutakis D, Liu Y, Loyo M, Agrawal N, Howard J, Li R, Ahn S, Fertig E, Sidransky D, Houghton J, Buddavarapu K, Sanford T, Choudhary A, Darden W, Adai A, Latham G, Bishop J, Sharma R, Westra WH, Hennessey P, Chung CH, Califano JA. Activation of the NOTCH pathway in head and neck cancer. Cancer Res. 2014 Feb 15;74(4):1091-104
  • Mydlarz W, Uemura M, Ahn S, Hennessey P, Chang S, Demokan S, Sun W, Shao C, Bishop J, Krosting J, Mambo E, Westra W, Ha P, Sidransky D, Califano J. Clusterin is a gene-specific target of microRNA-21 in head and neck squamous cell carcinoma. Clin Cancer Res. 2014 Feb 15;20(4):868-77
  • Hennessey PT, Francis HW, Gourin CG. Is there a "July effect" for head and neck cancer surgery? Laryngoscope. 2013 Aug;123(8):1889-95
  • Hennessey PT, Eisenberg LD, Deutsch ES.   Instrument Reprocessing in Otolaryngology. Update from the AAO-HNS Patient Safety and Quality Improvement Committee. The AAO-HNS Bulletin.
  • Hennessey PT and Reh DR.   Benign Sinonasal Neoplasms. American Journal of Rhinology and Allergy. 2013 May-Jun;27 Suppl 1:S31-4.
  • Hennessey PT, Semenov YR, Gourin CG. The Effect of Deep Venous Thrombosis on Short-term Outcomes and Cost of Care After Head and Neck Cancer Surgery. The Laryngoscope. 2013 Aug;123(8):1889-95.
  • Hennessey PT, Sanford T, Choudhary A, Mydlarz WW, Brown D, Adai AT, Ochs MF, Ahrendt SA, Mambo E, Califano JA. Serum miRNA Biomarkers for Detection of Non-Small Cell Lung Cancer. PLoS ONE. 2012; 7(2): e32307.
  • Hennessey PT, Ochs MF, Mydlarz WW, Hsueh W, Cope L, Yu W, Califano JA.Promoter methylation in head and neck squamous cell carcinoma cell lines is significantly different than methylation in primary tumors and xenografts. PLoS ONE, May 2011; 6(5): e20584. 
  • Shao C, Bai W, Junn JC, Uemura M, Hennessey PT, Zaboli D, Sidransky D, Califano JA, Ha PK. Evaluation of MYB Promoter Methylation in Salivary Adenoid Cystic Carcinoma. Oral Oncology, April 2010; 47(4): 2251-5.
  • Chang SS, Smith I, Glazer C, Hennessey P, Califano JA. EIF2C is overexpressed and amplified in head and neck squamous cell carcinoma. ORL J Otorhinolaryngol Relat Spec. 2010; 72(6): 337-43.
  • Mydlarz WK, Hennessey PT, Califano JA. Advances and Perspectives in the Molecular Diagnosis of Head and Neck Cancer. Expert Opin Med Diagn. January 2010; 4(1): 53-65.
  • Hennessey PT, Westra WH, and Califano JA. Human Papilloma Virus and Head and Neck Cancer: Recent Evidence and Clinical Implications. Journal of Dental Research, 2009; 88(4): 300-6.
  • Hanover JA, Forsythe ME, Hennessey PT, et al. A Caenorhabditis elegans model of insulin resistance: Altered macronutrient storage and dauer formation in an OGT-1 knockout. Proc Natl Acad Sci USA 2005; 102(32): 11266-71.